Leaky Gut

Intestino permeable (Leaky Gut) - Nootrópicos Perú

This comprehensive protocol for leaky gut is designed to repair the intestinal mucosa, reduce chronic inflammation, and restore barrier function. It is divided into three progressive phases: the first focuses on regenerating the intestinal wall with glutamine, zinc, carnosine, and butyrate; the second introduces probiotics, vitamin D, and curcumin to modulate immunity and stabilize the gut microbiota; and the third consolidates the results to prevent relapse. Each supplement has been selected for its specific action on cell junctions, intestinal mucus, or local inflammation. The program is complemented by nutritional strategies and takes into account digestive sensitivities. It is intended for people with symptoms such as bloating, fatigue, food intolerances, or autoimmune conditions. It is a gradual, effective, and restorative intervention.

🧬 PHASE 1: REDUCTION OF INFLAMMATION AND MUCOSAL REGENERATION (2 to 4 weeks)

Objective: To reduce intestinal inflammation, restore the integrity of the epithelial barrier, and soothe the mucosa.

🔹 L-Alanyl-L-Glutamine (Sustamine)

Glutamine is the primary fuel for enterocytes, the cells that make up the intestinal wall. It promotes mucosal regeneration, reduces intestinal permeability, and improves the function of tight junctions. The Sustamine form enhances its absorption and stability in damaged intestinal environments.

🔹 Zinc Carnosine

The combination of zinc and carnosine has healing effects on the gastric and intestinal mucosa. It stimulates epithelial renewal, reduces inflammation, and improves the integrity of cell junctions. It is one of the most studied ingredients for repairing intestinal damage, working synergistically with glutamine.

🔹 N-Acetyl Glucosamine (NAG)

NAG is a precursor to the glycoconjugates that make up intestinal mucus. It repairs the protective mucous layer of the intestine and improves local immune tolerance, especially useful in sensitized intestines or those with food allergies. It reduces excessive immune activation in the mucosa.

🔹 Hyaluronic Acid (150mg daily)

Hyaluronic acid not only hydrates the intestinal mucosa but also forms part of the intestinal extracellular matrix. It promotes epithelial regeneration, modulates local inflammation, and improves the viscosity of intestinal mucus, acting as an additional physical barrier.

🔹 Sodium Butyrate

Butyrate is a short-chain fatty acid that reduces inflammation, improves cell adhesion, and promotes intestinal barrier repair. It also positively modulates the gut microbiota and fosters a more stable intestinal environment.

🧪 PHASE 2: IMMUNE MODULATION AND MICROBIOTA (3 to 6 weeks)

Objective: To stabilize the intestinal immune system and recolonize with beneficial bacteria that strengthen the barrier.

🔹 Lactobacillus Reuteri

These strains produce metabolites that strengthen tight junctions, reduce intestinal inflammation, and inhibit pathogen growth. L. reuteri, in particular, is very effective at modulating the gut-brain axis and local immunity. They should be taken separately from antimicrobials if antimicrobials are being used.

🔹 Vitamin D3 + K2

Vitamin D regulates mucosal immunity, promotes the expression of proteins that stabilize the intestinal barrier, and reduces chronic inflammation. Its combination with vitamin K2 improves bioavailability and systemic effect. This is especially useful in individuals with a history of autoimmunity.

🔹 Curcumin 98% + piperine

Curcumin modulates inflammatory cytokines (TNF-α, IL-6), protects against intestinal oxidative damage, and improves epithelial integrity. It can reduce symptoms such as bloating, pain, and excessive permeability when used in liposomal forms or with piperine.

🔁 PHASE 3: MAINTENANCE AND RELAPSE PREVENTION (minimum 2 to 3 months)

Objective: To consolidate intestinal regeneration, prevent relapses, and strengthen long-term immune balance.

🔹 Sodium Butyrate

It maintains the integrity of the intestinal epithelium, strengthens immune tolerance, and prevents relapses in intestinal permeability.

🔹 L-Alanyl-L-Glutamine (Sustamine)

Prolonged use at low doses maintains enterocyte regeneration, especially useful in contexts of stress, occasional inflammatory diet or recovery from infections.

🔹 Reuteri

They prevent recolonization of pathogens, support the production of SCFAs (short-chain fatty acids), and promote intestinal immune balance.

✅ OPTIONAL DEPENDING ON INDIVIDUAL CASE

  • Gastroreparator (BPC-157, GHK-Cu, KPV)
    ➤ They enhance intestinal regeneration and reduce chronic inflammation in severe cases.
  • C15 (Pentadecanoic acid)
    ➤ They reinforce intestinal anti-inflammatory action by modulating the cell membrane.
  • Lactoferrin 98%
    ➤ Improves intestinal defenses and modulates the microbiota in people with frequent infections or SIBO.

FULL PROGRAM

🔵 PHASE 1 – INTESTINAL BARRIER REPAIR (Weeks 1 to 4)

Objective: To soothe the mucosa, close permeable junctions, reduce local inflammation, and regenerate the intestinal epithelium.

🕗 MORNING (ON AN EMPTY STOMACH)

🍽️ BREAKFAST

🌙 BEFORE SLEEPING

📆 Duration: 3 to 4 weeks (minimum 21 days for sustained results).

🔵 PHASE 2 – IMMUNE MODULATION AND MICROBIAL REPOPULATION (Weeks 5 to 8)

Objective: To strengthen local defenses, suppress persistent inflammation, and recolonize with protective strains.

🕗 MORNING (ON AN EMPTY STOMACH)

🍽️ BREAKFAST

🍽️ LUNCH

🌙 BEFORE SLEEPING

📆 Duration: 4 weeks. Ideally, evaluate symptoms and adjust probiotic dose if there is sensitivity.

🔵 PHASE 3 – MAINTENANCE AND RELAPSE PREVENTION (minimum 2 months)

Objective: To maintain the benefits achieved, stabilize the intestinal ecosystem and prevent future disruptions.

🕗 MORNING (ON AN EMPTY STOMACH)

🍽️ LUNCH

🌙 BEFORE SLEEPING

📆 Duration: 2 to 3 months. May be extended depending on digestive history.

⚠️ ADDITIONAL RECOMMENDATIONS

  • Avoid gluten, dairy, refined sugar, and alcohol throughout the protocol.
  • Increase intake of bone broth, cooked vegetables, mild prebiotics such as green banana, and non-irritating fibers.
  • Drink at least 2L of water daily.
  • Practice mindful eating to reduce digestive stress.
  • It can be combined with SIBO, antifungal, or antiparasitic protocols as needed.