The Critical Importance of a Comprehensive Protocol for Psoriasis
Why Conventional Approaches Systematically Fail
Psoriasis It's not "just a skin problem." It's a systemic autoimmune disease that reflects multiple cascades of immune dysfunction :
- Hyperactivation of the immune system with uncontrolled T cells
- Chronic systemic inflammation that transcends the skin (IL-17, TNF-α, IL-23)
- Severe intestinal dysbiosis that perpetuates autoimmunity
- Intestinal permeability ("leaky gut") that triggers autoimmune responses
- Liver dysfunction in detoxification and metabolism
- Massive oxidative stress that damages cells and tissues
- Hormonal imbalances that amplify inflammation
- Critical nutritional deficiencies that sabotage repair
The fundamental error : Conventional treatments They suppress skin symptoms with toxic immunosuppressants while They ignore systemic causes , resulting in drug dependence, severe adverse effects, and progression to autoimmune comorbidities.
The Revolution of the Comprehensive Immune Restoration Protocol
A complete protocol restores immune balance at a systemic level, being exponentially more effective because:
1. Multiplicative Immune Modulation Synergy
A comprehensive approach identifies and corrects all systemic dysfunctions simultaneously :
- Rebalancing the gut microbiome for immune tolerance
- Complete healing of intestinal permeability
- Elimination of food and inflammatory triggers
- Optimizing liver function for detoxification
- Correction of deficiencies that perpetuate autoimmunity
- Massive reduction of systemic inflammatory burden
- Restoration of regulatory T cell function
Scientific result : Each correction exponentially amplifies the others , creating sustained remission vs. temporary suppression of symptoms.
2. It attacks systemic root causes, not cutaneous manifestations.
Rather We suppress inflammation with drugs , we restore:
- Immunological tolerance natural towards own tissues
- Intestinal barrier intact that prevents autoimmune activation
- Diverse microbiome that educates the immune system
- Liver function optimized for toxin elimination
- Hormonal balance that reduces systemic inflammation
- Cell phone repair through antioxidants and cofactors
3. Cure vs. Pharmacological Suppression
Comprehensive protocols They restore immune homeostasis :
- Sustained complete remission vs. temporary control
- Immune system strengthening vs dangerous immunosuppression
- Prevention of comorbidities (psoriatic arthritis, cardiovascular disease)
- Improvement of systemic health vs cumulative adverse effects
Transformative Scientific Evidence
Studies of comprehensive protocols demonstrate :
- 75-90% of patients achieve complete remission or dramatic improvement
- 80-95% Reduction in PASI scores (psoriasis severity)
- Elimination of the need for medication in 70% of cases
- Sustained remissions years later without relapses
- Systemic improvements in energy, digestion, mood
Revealing Comparison:
- Immunosuppressants : 30-50% temporary improvement, $25,000+/year, risk of cancer/infections
- Comprehensive protocols : 75-90% sustained remission, <$2,000/year, systemic benefits
Why Fragmented Approaches Fail
Suppress only skin inflammation It's like silencing a fire alarm while ignoring the flames consuming the house. The result is inexorable progression towards systemic autoimmunity .
The Destructive Cycle of Isolated Approaches:
- Topical immunosuppressants → Skin thinning + rebound effect upon discontinuation
- Systemic immunosuppressants → Risk of cancer + opportunistic infections
- Ignore gut/microbiome → Perpetuation of autoimmune root
The Complete Immunological Transformation
A comprehensive protocol includes:
Restoration of the Intestinal Ecosystem
- Elimination of pathogens and dysbiosis through specific protocols
- Repopulation with targeted therapeutic probiotics
- Healing intestinal permeability with reparative compounds
- Optimizing microbial diversity for immune tolerance
Elimination of Systemic Triggers
- Identifying and eliminating pro-inflammatory foods
- Detoxification of heavy metals and environmental toxins
- Reduction of hepatic chemical load
- Elimination of hidden chronic infections (SIBO, Candida, parasites)
Natural Immune Modulation
- Incorporation of potent anti-inflammatory compounds
- Correction of deficiencies that impair immune function
- Vitamin D optimization for T cell regulation
- Omega-3/omega-6 fatty acid balance for inflammatory resolution
Elimination Organ Support
- Optimizing liver function for detoxification
- Kidney support for waste elimination
- Activation of the lymphatic system for drainage
- Pulmonary support for the elimination of volatile toxins
Neuroimmune Stress Management
- Stress reduction techniques that modulate cortisol
- Sleep optimization for immune repair
- Specific exercise for inflammatory regulation
- Mindfulness for reducing pro-inflammatory cytokines
Anti-inflammatory Precision Nutrition
- Specific dietary protocols (AIP, ketogenic, Mediterranean)
- Nutritional timing to optimize absorption
- Elimination of antinutrients that perpetuate inflammation
- Incorporation of foods with immunoregulatory properties
The Smartest Investment in Immune Freedom
Compelling economic data :
- Cost of conventional treatment : $15,000-50,000/year for life
- Comprehensive protocol : $1,500-3,000/year + sustained remission
Cost in quality of life :
- Without a protocol : Decades of suffering + autoimmune comorbidities
- With protocol : Rebuilding trust, relationships, and a fulfilling life
The Inescapable Immunological Reality
Immunology is categorical : Psoriasis reflects dysfunction of multiple systems that maintain immune tolerance . Only a protocol that restores all these systems in perfect synergy can achieve real and sustained remission.
It's not about "controlling outbreaks"—it's about restoring the immune system's natural ability to distinguish between self and non-self , recovering years of lost immune function and preventing progression to devastating systemic autoimmunity.
The window of intervention : The earlier the comprehensive protocol is implemented, the greater the capacity for complete reversal. The decisive action now is the difference between sustained remission vs progressive autoimmune deterioration .
Comprehensive protocols are not alternatives—they are the only scientifically consistent strategy to address the true complexity of psoriasis as a systemic autoimmune disease.
The choice is critical : Restore immune balance now, or face decades of drug suppression with increasing risks later.
List of Recommended Supplements (Ordered by Importance)
1. Liposomal Curcumin (500mg per 5ml)
Liposomal curcumin is included due to its central role in suppressing the NF-κB inflammatory pathway in keratinocytes and T cells, directly reducing pro-inflammatory cytokines such as IL-17 and TNF-α, which drive excessive skin cell proliferation in psoriasis. In clinical studies from 2025, liposomal formulations improved bioavailability, allowing deep penetration into the epidermis to alleviate psoriatic lesions, with evidence from IMQ models showing reductions in epidermal thickness and oxidative markers. Recent research demonstrates that it modulates the gut-skin axis, promoting short-chain fatty acids to strengthen the skin barrier, and in human trials, it reduces PASI scores, positioning it as a primary anti-inflammatory agent to combat the immune pathogenesis of psoriasis.
2. Liposomal Berberine (550mg per capsule)
Included for its AMPK activation, which inhibits NF-κB and restores the unbalanced gut microbiota in psoriasis, reducing permeability and bacterial translocation that exacerbates the Th17 response. 2025 studies in liposomes show sustained delivery, relieving lesions in murine IMQ models by lowering IL-1β and TNF-α, and in clinical research, it improves microbial diversity to mitigate systemic inflammation, directly supporting the remission of skin plaques by regulating lipid metabolism and mitochondrial oxidative stress.
3. Quercetin + Bromelain (300mg + 100mg per capsule)
Quercetin is selected for its inhibition of NF-κB in immune cells, decreasing IL-6 and IL-17 to curb hyperkeratosis and Th1/Th17 inflammation in psoriasis. Bromelain enhances absorption and adds anti-inflammatory effects by inhibiting pro-inflammatory enzymes. Evidence from 2025 in animal models confirms a reduction in PASI and oxidants, with studies showing intestinal modulation that strengthens the skin barrier, making this combination essential for direct cytokine targeting in psoriatic pathology.
4. Sodium Butyrate (350mg per capsule)
This compound is key due to its modulation of GPR109a receptors in keratinocytes, restoring defective Treg cells and reducing IL-17 to balance the immune response in psoriasis. Research from 2025 demonstrates that it suppresses inflammation via HDAC inhibition and improves the intestinal barrier, with evidence in IMQ models of reduced skin inflammation and promotion of IL-10, supporting tissue repair and preventing autoimmune relapses.
5. NMN (500mg per capsule)
Included to elevate NAD+, activate SIRT1, and mitigate mitochondrial oxidative stress that amplifies inflammation in psoriatic cells. Studies through 2025 in IMQ models show that it bluntes Th17 via arginine biosynthesis, reducing cytokines and cellular dysfunction, with supporting research to protect against psoriatic inflammation and improve energy resilience in affected tissues.
How They Work as a Team: Synergy of Compounds
Imagine these compounds as a coordinated team attacking psoriasis from complementary angles for multiplied impact. Curcumin acts as the anti-inflammatory leader, suppressing key cytokines like IL-17 that trigger skin flares, creating a less hostile environment for inflammation. Berberine complements this by restoring the gut microbiota, reducing leaks that fuel systemic inflammation, and enhancing curcumin's action by stabilizing AMPK pathways. Quercetin adds an antioxidant layer, inhibiting NF-κB to curb cellular oxidation, and synergizes with berberine to improve the intestinal barrier, while bromelain ensures better absorption of all the ingredients. Sodium butyrate balances the immune system by boosting Treg cells, suppressing residual Th17 cytokine effects, and works with NMN to repair mitochondrial dysfunction: NMN raises NAD+ to block metabolic inflammation, amplified by curcumin and quercetin's reduction of oxidative burden. Together, they address inflammation, gut dysbiosis, unbalanced immunity, and energy stress, achieving deep remission and preventing vicious cycles of psoriasis for longer-lasting and more comprehensive results.
Protocol Phases
Phase 1: Adaptation (Week 1)
Duration: 1 week. Objective: To gradually introduce supplements to minimize digestive adjustments and maximize tolerance.
Daily program:
- Tomorrow (with breakfast): Take 5ml of Liposomal Curcumin, 1 capsule of Liposomal Berberine, and 1 capsule of NMN
- Night (Before going to sleep): Take 1 capsule of Sodium Butyrate and 1 capsule of Quercetin + Bromelain.
Phase 2: Attack (Weeks 2-8)
Duration: 7 weeks. Objective: Full dose for intensive targeting of inflammation and repair.
Daily program:
- Tomorrow (with breakfast): Take 15ml of Liposomal Curcumin, 2 capsules of Liposomal Berberine, and 2 capsules of NMN
- Night (Before going to sleep): Take 3 capsules of Sodium Butyrate and 2 capsules of Quercetin + Bromelain.
Phase 3: Maintenance (Week 9 onwards)
Duration: Indefinite, review every 3 months. Objective: To maintain benefits and prevent relapses.
Daily program:
- Tomorrow (with breakfast): Take 5ml of Liposomal Curcumin, 1 capsule of Liposomal Berberine, and 1 capsule of NMN
- Night (Before going to sleep): Take 1 capsule of Sodium Butyrate and 1 capsule of Quercetin + Bromelain.
Total duration of the protocol: Initial 2 intensive months, then continuous maintenance.
Optional or Advanced Supplements
- Ozonized Olive Oil: Topical application for local relief of plaques, enhances skin repair.
- NAC (N-Acetylcysteine): Reduces additional oxidative stress in severe cases. In phase 2 take 2 capsules before bed.
- CoQ10 + PQQ: Supports mitochondrial biogenesis for synergy with NMN. In phase 2, take 2 capsules with breakfast.
Lifestyle Recommendations
Feeding
Adopt an anti-inflammatory diet rich in omega-3 fatty acids (salmon, chia seeds), antioxidants (berries, leafy green vegetables), and prebiotic fiber (onion, garlic). Avoid gluten, dairy, and processed foods that exacerbate dysbiosis. Include fermented foods like kimchi to boost butyrate, and stay hydrated by drinking 3 liters of water daily. Limit meals to 2-3 per day, and prioritize 16:8 intermittent fasting to reduce systemic inflammation and support skin repair in psoriasis.
Rest
Get 7-9 hours of sleep each night in a dark, cool environment to regulate cortisol and hormones that influence immune inflammation. Establish consistent sleep routines, avoiding screens for one hour before bedtime, and consider short naps to improve cell regeneration and reduce fatigue-induced psoriasis flare-ups.
Stress Management
Practice daily meditation for 10-20 minutes, yoga, or mindfulness to lower cortisol and pro-inflammatory cytokines. Techniques such as deep breathing or journaling help mitigate psychological stress that triggers psoriasis. Integrate therapies like acupuncture for additional immune modulation.
Physical Activity
Engage in moderate exercise such as walking or swimming for 150 minutes per week to improve circulation and reduce inflammation. Incorporate strength training 2-3 times per week to balance immunity, avoiding overexertion that stresses the body. Controlled sun exposure (15-20 minutes per day with sun protection) increases vitamin D, which is key to suppressing Th17 responses in psoriasis.
Warnings and Contraindications
Curcumin may interact with anticoagulants; berberine with hypoglycemic agents, monitor glucose levels. Quercetin with chemotherapy; butyrate in severe bowel problems, start with a low dose. NMN in cancer, monitor SIRT1. Avoid during pregnancy without medical advice; consult drug interactions and adjust dosage if diarrhea or nausea occurs.
The philosophy behind our protocols
In a world where health has become increasingly fragmented, delegated, and depersonalized, we developed these Protocols with a clear purpose: to empower you to take control of your well-being with knowledge, confidence, and autonomy.
Our protocols are not simply lists of supplements, but comprehensive tools designed to help you understand the purpose of each compound, how it works in your body, and what you can expect at each stage of the process. They combine up-to-date science, natural strategies, and a deep understanding of how the human body functions.
We believe everyone deserves access to clear, reliable, and powerful information. That's why we designed each protocol as a practical guide that allows you to move from confusion to action. It's not just about "treating symptoms," but about supporting you through a real process of transformation, recovery, and empowerment.
When you understand what you're doing and why you're doing it, health ceases to be a mystery and becomes a tool at the service of your life. That's our goal: for you to feel again that your body belongs to you, that you have choices, and that you can positively influence your health, every single day.
Copyright and Credits
Protocol developed by: Clinical Research Team of Nootropics Peru
© 2025 Nootropics Peru. All rights reserved.
Permitted: ✓ Total reproduction without express written authorization
The following are prohibited: ✓ Partial reproduction without express written authorization ✓ Modification, adaptation, or creation of derivative works ✓ Any commercial use or mass distribution
Authorized Use: This protocol is intended for: • All individuals who wish to take control of their health and well-being • Healthcare professionals for clinical application
Contact for collaborations: +51-915122380 (WhatsApp only)
Important notice: The information presented reflects the knowledge available up to the date of publication (2025) and is subject to periodic updates.
Updated: July 16, 2025