METHYLENE BLUE DOSAGE: EVERYTHING YOU NEED TO KNOW

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METHYLENE BLUE DOSAGE: EVERYTHING YOU NEED TO KNOW

Methylene blue is a compound used for various therapeutic purposes, and understanding its proper dosage is essential for safely obtaining maximum benefits. Here, we will discuss how to calculate dosages for a 1% solution, considering factors such as the amount per drop, daily requirements based on body weight, and best practices for its use.

How many milligrams does a 1% solution contain?

When we talk about a 1% methylene blue solution, this means it contains 10 mg of methylene blue per milliliter (ml). This calculation is based on the fact that water has an approximate density of 1 gram per milliliter, allowing us to deduce that 1% of 1 gram is equivalent to 10 mg.

Therefore, 1 ml of 1% solution contains 10 mg of methylene blue.

How many milligrams are in a drop?

20 drops per milliliter
If we consider that 1ml is equivalent to 20 drops, then each drop contains 0.5mg of methylene blue.

Calculation of the daily dose according to body weight

Scientific literature suggests that therapeutic doses of methylene blue range from 0.5 mg/kg to 4 mg/kg of body weight per day. Here we explain how to calculate them:

Example for a person weighing 100kg (220 pounds):

Minimum dose (0.5mg/kg):

If each drop contains 0.5mg, you would need
Alternatively, you could consume 2.5ml if you use a syringe or a graduated dropper.

Maximum dose (4mg/kg):

With a concentration of 0.5 mg per drop, this is impractical. In this case, a more concentrated solution would be recommended.

Considerations on the quality of methylene blue

It is essential to ensure that the methylene blue used is USP grade (United States Pharmacopeia). This guarantees adequate purity and minimizes the risk of impurities or contaminants. Additionally, it is important to evaluate the cost-benefit ratio, as higher doses may require a significant quantity of the product.

Final recommendations

Start with low doses: It's always best to start with a conservative dose to assess tolerance before gradually increasing.

Adapt the dose to your needs: Adjust the amount according to the therapeutic benefits observed and your body weight.

Consult reliable sources: If you have doubts, look for specialized clinical guidelines or train with qualified professionals.


Methylene blue can be a powerful therapeutic tool when used correctly. With this information, you can now calculate dosages accurately and safely to maximize its benefits.